The present manuscript describe simple, sensitive, rapid, accurate, precise and economical Q-absorbance method for the simultaneous determination of olmesartan medoxomil (OLME) and cilnidipine (CILNI) in their combined pharmaceutical dosage form. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an isoabsorptive point at 270 nm in methanol. The second wavelength is used 241 nm, which is λmax of olmesartan medoxomil in Methanol. Linearity was observed for olmesartan medoxomil and for cilnidipine in the concentration range of 4-20 μg/ml and (r2 = 0.996) and 2-10 μg/ml and (r2 = 0.999). The concentration of drugs was determined by using ratio of absorbance at isoabsorptive point and at the λmax of cilnidipine. The method was successfully applied to pharmaceutical dosage form because of no interference. The result of analysis has been validated by recovery studies.
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